Please use this identifier to cite or link to this item:
|Title:||Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface.||Authors:||Zhang, H.F.
|Issue Date:||1997||Citation:||Zhang, H.F., Ong, W.Y., Leong, S.K., Laperche, Y. (1997). Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface.. Journal für Hirnforschung 38 (3) : 323-330. ScholarBank@NUS Repository.||Abstract:||The expression of gamma-glutamyl transpeptidase (GGT) has been associated with the emergence of a functional blood-brain barrier. We have undertaken a precise localisation of this enzyme in the cerebral cortical vessels of different species, by immunocytochemistry using a polyclonal antibody and light and electron microscopy. GGT immunoreaction product was present on the luminal surface of endothelial cells in 1-day-old to 3-month-old rats, whereas in the mouse, monkey and human cortex, this protein was present in astrocytic endfeet around the vessels. No labelling was observed in the other cellular components of the vessel walls, such as pericytes, fibroblasts, smooth muscle cells and perivascular cells. The localisation of GGT in astrocytes in mice, monkeys and humans suggests that these cells could play a role in the detoxication of lipophilic xenobiotic substances that cross the endothelial barrier. In these species, astrocytes can be viewed as a second line of defense against xenobiotics, beyond the capillary endothelium.||Source Title:||Journal für Hirnforschung||URI:||http://scholarbank.nus.edu.sg/handle/10635/131915||ISSN:||00218359|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 22, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.