Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131915
DC FieldValue
dc.titleSpecies differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface.
dc.contributor.authorZhang, H.F.
dc.contributor.authorOng, W.Y.
dc.contributor.authorLeong, S.K.
dc.contributor.authorLaperche, Y.
dc.date.accessioned2016-11-29T02:50:09Z
dc.date.available2016-11-29T02:50:09Z
dc.date.issued1997
dc.identifier.citationZhang, H.F., Ong, W.Y., Leong, S.K., Laperche, Y. (1997). Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface.. Journal für Hirnforschung 38 (3) : 323-330. ScholarBank@NUS Repository.
dc.identifier.issn00218359
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131915
dc.description.abstractThe expression of gamma-glutamyl transpeptidase (GGT) has been associated with the emergence of a functional blood-brain barrier. We have undertaken a precise localisation of this enzyme in the cerebral cortical vessels of different species, by immunocytochemistry using a polyclonal antibody and light and electron microscopy. GGT immunoreaction product was present on the luminal surface of endothelial cells in 1-day-old to 3-month-old rats, whereas in the mouse, monkey and human cortex, this protein was present in astrocytic endfeet around the vessels. No labelling was observed in the other cellular components of the vessel walls, such as pericytes, fibroblasts, smooth muscle cells and perivascular cells. The localisation of GGT in astrocytes in mice, monkeys and humans suggests that these cells could play a role in the detoxication of lipophilic xenobiotic substances that cross the endothelial barrier. In these species, astrocytes can be viewed as a second line of defense against xenobiotics, beyond the capillary endothelium.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.sourcetitleJournal für Hirnforschung
dc.description.volume38
dc.description.issue3
dc.description.page323-330
dc.identifier.isiutNOT_IN_WOS
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