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Title: Long-term post-liver transplant complications of renal impairment and diabetes mellitus: Data from Singapore
Authors: Sutedja, D.S.
Wai, C.T. 
Teoh, K.F.
Lee, Y.M. 
Diddapur, R.K.
Isaac, J. 
Mak, K.
Da Costa, M.
Lee, K.H. 
Prabhakaran, K. 
Tan, K.C.
Lim, S.G. 
Keywords: Diabetes mellitus
Glomerular filtration rate
Liver transplant
Liver transplant complications
Renal impairment
Issue Date: Jul-2006
Citation: Sutedja, D.S., Wai, C.T., Teoh, K.F., Lee, Y.M., Diddapur, R.K., Isaac, J., Mak, K., Da Costa, M., Lee, K.H., Prabhakaran, K., Tan, K.C., Lim, S.G. (2006-07). Long-term post-liver transplant complications of renal impairment and diabetes mellitus: Data from Singapore. Singapore Medical Journal 47 (7) : 604-608. ScholarBank@NUS Repository.
Abstract: Introduction: Patients who survive the initial post-liver transplantation period face the development of chronic diseases in the long run. We studied two important complications of liver transplantation, namely: renal impairment and diabetes mellitus. Methods: We analysed adult patients followed-up for more than one year using data from our liver transplant clinical records. Long-term post-transplant renal impairment (RI) was defined as glomerular filtration rate (GFR) less than 60 ml/min/1.73 square metres and long-term post-transplant diabetes mellitus (DM) was defined as fasting blood glucose more than 7.8 mmol/L, that existed at least one year after liver transplantation. Pre- and post-transplant factors that could be associated with these conditions were examined. Results: Altogether, 35 patients were evaluated. Mean age at transplant was 50 years. Mean duration of follow-up was 58.4 months. There was 11.4 percent of pre-transplant RI and 17.0 percent of pre-transplant DM. Prevalence of post-transplant RI was 43.5 percent at one year and 45.0 percent at four years. Long-term post-transplant RI was associated with renal impairment at six months post-transplant (p-value is 0.033). Prevalence of severe post-transplant RI (GFR is less than 30 ml/min/1.73 square metres) at four years was 5.7 percent. Prevalence of post transplant DM was 45.5 percent at two years but declined to 5.3 percent at four years. Conclusion: Post-transplant renal impairment appears to be a potential long-term problem while post-transplant diabetes mellitus appears to improve with time.
Source Title: Singapore Medical Journal
ISSN: 00375675
Appears in Collections:Staff Publications

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