Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131595
Title: Long-term post-liver transplant complications of renal impairment and diabetes mellitus: Data from Singapore
Authors: Sutedja, D.S.
Wai, C.T. 
Teoh, K.F.
Lee, Y.M. 
Diddapur, R.K.
Isaac, J. 
Mak, K.
Da Costa, M.
Lee, K.H. 
Prabhakaran, K. 
Tan, K.C.
Lim, S.G. 
Keywords: Diabetes mellitus
Glomerular filtration rate
Liver transplant
Liver transplant complications
Renal impairment
Issue Date: Jul-2006
Source: Sutedja, D.S., Wai, C.T., Teoh, K.F., Lee, Y.M., Diddapur, R.K., Isaac, J., Mak, K., Da Costa, M., Lee, K.H., Prabhakaran, K., Tan, K.C., Lim, S.G. (2006-07). Long-term post-liver transplant complications of renal impairment and diabetes mellitus: Data from Singapore. Singapore Medical Journal 47 (7) : 604-608. ScholarBank@NUS Repository.
Abstract: Introduction: Patients who survive the initial post-liver transplantation period face the development of chronic diseases in the long run. We studied two important complications of liver transplantation, namely: renal impairment and diabetes mellitus. Methods: We analysed adult patients followed-up for more than one year using data from our liver transplant clinical records. Long-term post-transplant renal impairment (RI) was defined as glomerular filtration rate (GFR) less than 60 ml/min/1.73 square metres and long-term post-transplant diabetes mellitus (DM) was defined as fasting blood glucose more than 7.8 mmol/L, that existed at least one year after liver transplantation. Pre- and post-transplant factors that could be associated with these conditions were examined. Results: Altogether, 35 patients were evaluated. Mean age at transplant was 50 years. Mean duration of follow-up was 58.4 months. There was 11.4 percent of pre-transplant RI and 17.0 percent of pre-transplant DM. Prevalence of post-transplant RI was 43.5 percent at one year and 45.0 percent at four years. Long-term post-transplant RI was associated with renal impairment at six months post-transplant (p-value is 0.033). Prevalence of severe post-transplant RI (GFR is less than 30 ml/min/1.73 square metres) at four years was 5.7 percent. Prevalence of post transplant DM was 45.5 percent at two years but declined to 5.3 percent at four years. Conclusion: Post-transplant renal impairment appears to be a potential long-term problem while post-transplant diabetes mellitus appears to improve with time.
Source Title: Singapore Medical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/131595
ISSN: 00375675
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

11
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.