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Title: Fine needle aspiration biopsy of hepatocellular carcinoma: Some unusual features
Authors: Wee, A. 
Nilsson, B. 
Chan-Wilde, C. 
Yap, I. 
Issue Date: 1991
Citation: Wee, A., Nilsson, B., Chan-Wilde, C., Yap, I. (1991). Fine needle aspiration biopsy of hepatocellular carcinoma: Some unusual features. Acta Cytologica 35 (6) : 661-670. ScholarBank@NUS Repository.
Abstract: The cytologic features of fine needle aspiration smears from 28 hepatocellular carcinomas (HCC) were reviewed. All aspirations except one were guided. There were 14 well-, 11 moderately and 3 poorly differentiated HCC. The better-differentiated HCC were characterized by similarity of the tumor cells to hepatocytes (83%), cohesive cell clusters with a trabecular arrangement (72%) and presence of sinusoidal endothelial cells (66%). Other features included bile production (38%), atypical hepatocytic naked nuclei (52%), acinar formation (31%), intracytoplasmic vacuoles (14%) and abnormal vascular patterns (14%). Poorly differentiated HCC showed dyshesive pleomorphic cells. Unusual cytologic features from a well-differentiated HCC with fatty change and an HCC with a prominent acinar component are described. The identification of fatty change in dissociated well-differentiated hepatocytes or cytologic features suggestive of an adenocarcinoma do not preclude the diagnosis of HCC. The usefulness of cell blocks is emphasized.
Source Title: Acta Cytologica
ISSN: 00015547
Appears in Collections:Staff Publications

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