Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131383
DC FieldValue
dc.titleFine needle aspiration biopsy of hepatocellular carcinoma: Some unusual features
dc.contributor.authorWee, A.
dc.contributor.authorNilsson, B.
dc.contributor.authorChan-Wilde, C.
dc.contributor.authorYap, I.
dc.date.accessioned2016-11-28T10:19:34Z
dc.date.available2016-11-28T10:19:34Z
dc.date.issued1991
dc.identifier.citationWee, A., Nilsson, B., Chan-Wilde, C., Yap, I. (1991). Fine needle aspiration biopsy of hepatocellular carcinoma: Some unusual features. Acta Cytologica 35 (6) : 661-670. ScholarBank@NUS Repository.
dc.identifier.issn00015547
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131383
dc.description.abstractThe cytologic features of fine needle aspiration smears from 28 hepatocellular carcinomas (HCC) were reviewed. All aspirations except one were guided. There were 14 well-, 11 moderately and 3 poorly differentiated HCC. The better-differentiated HCC were characterized by similarity of the tumor cells to hepatocytes (83%), cohesive cell clusters with a trabecular arrangement (72%) and presence of sinusoidal endothelial cells (66%). Other features included bile production (38%), atypical hepatocytic naked nuclei (52%), acinar formation (31%), intracytoplasmic vacuoles (14%) and abnormal vascular patterns (14%). Poorly differentiated HCC showed dyshesive pleomorphic cells. Unusual cytologic features from a well-differentiated HCC with fatty change and an HCC with a prominent acinar component are described. The identification of fatty change in dissociated well-differentiated hepatocytes or cytologic features suggestive of an adenocarcinoma do not preclude the diagnosis of HCC. The usefulness of cell blocks is emphasized.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.contributor.departmentMEDICINE
dc.description.sourcetitleActa Cytologica
dc.description.volume35
dc.description.issue6
dc.description.page661-670
dc.description.codenACYTA
dc.identifier.isiutNOT_IN_WOS
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