Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131038
Title: Inhibition of platelet aggregation with intravenous and oral administration of a carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483) in man
Authors: Adaikan, P.G.
Lau, L.C. 
Tai, M.Y.
Karim, S.M.M.
Issue Date: 1983
Citation: Adaikan, P.G., Lau, L.C., Tai, M.Y., Karim, S.M.M. (1983). Inhibition of platelet aggregation with intravenous and oral administration of a carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483) in man. Prostaglandins Leukotrienes and Medicine 10 (1) : 53-64. ScholarBank@NUS Repository.
Abstract: Intravenous and oral administration of a chemically stable carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483), resulted in ex-vivo inhibition of ADP-induced platelet aggregation in man. The maximum tolerated intravenous dose was 2.5 ng/kg/min for 1 hour and this produced a mean of 27.1% inhibition in 3 volunteers. For oral administration the tolerated single dose was 200 μg. At this dose, there was 56.3% inhibition of aggregation (mean of 3 results). High oral (400 μg) and intravenous doses (5 and 10 ng/kg/min for 1 hour) of ONO 41483, which caused marked inhibition of aggregation (ranging 39-100%), was accompanied by flushing of face and extremities, headache and phlebitis. However, none of the doses tested produced significant changes in arterial blood pressure or heart rate.
Source Title: Prostaglandins Leukotrienes and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/131038
ISSN: 02621746
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

27
checked on Jun 6, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.