Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/131038
Title: Inhibition of platelet aggregation with intravenous and oral administration of a carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483) in man
Authors: Adaikan, P.G.
Lau, L.C. 
Tai, M.Y.
Karim, S.M.M.
Issue Date: 1983
Source: Adaikan, P.G., Lau, L.C., Tai, M.Y., Karim, S.M.M. (1983). Inhibition of platelet aggregation with intravenous and oral administration of a carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483) in man. Prostaglandins Leukotrienes and Medicine 10 (1) : 53-64. ScholarBank@NUS Repository.
Abstract: Intravenous and oral administration of a chemically stable carboprostacyclin analogue, 15-cyclopentyl-ω-pentanor-5(E)-carbacyclin (ONO 41483), resulted in ex-vivo inhibition of ADP-induced platelet aggregation in man. The maximum tolerated intravenous dose was 2.5 ng/kg/min for 1 hour and this produced a mean of 27.1% inhibition in 3 volunteers. For oral administration the tolerated single dose was 200 μg. At this dose, there was 56.3% inhibition of aggregation (mean of 3 results). High oral (400 μg) and intravenous doses (5 and 10 ng/kg/min for 1 hour) of ONO 41483, which caused marked inhibition of aggregation (ranging 39-100%), was accompanied by flushing of face and extremities, headache and phlebitis. However, none of the doses tested produced significant changes in arterial blood pressure or heart rate.
Source Title: Prostaglandins Leukotrienes and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/131038
ISSN: 02621746
Appears in Collections:Staff Publications

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