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Title: Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats
Authors: Cheng, R.-K.
Scott, A.C.
Penney, T.B. 
Williams, C.L.
Meck, W.H.
Keywords: Attention
Clock speed
Cognitive aging
Interval timing
Modality differences
Neural development
Prefrontal cortex
Prenatal nutrition
Stimulus intensity
Time perception
Issue Date: 27-Oct-2008
Citation: Cheng, R.-K., Scott, A.C., Penney, T.B., Williams, C.L., Meck, W.H. (2008-10-27). Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats. Brain Research 1237 : 167-175. ScholarBank@NUS Repository.
Abstract: Choline supplementation of the maternal diet has a long-term facilitative effect on the interval-timing ability and temporal memory of the offspring. Here, we examined whether prenatal-choline supplementation has modality-specific effects on duration discrimination in aged (20 mo) male rats. Adult offspring of rats that were given sufficient choline in their chow (CON: 1.1 g/kg) or supplemental choline added to their drinking water (SUP: 3.5 g/kg) during embryonic days (ED) 12-17 were trained and tested on a two-modality (auditory and visual signals) duration bisection procedure (2 s vs. 8 s). Intensity (high vs. low) of the auditory and visual timing signals was systematically manipulated across test sessions such that all combinations of signal intensity by modality were tested. Psychometric response functions indicated that prenatal-choline supplementation systematically increased sensitivity to auditory signals relative to visual signals, thereby magnifying the modality effect that sounds are judged to be longer than lights of equivalent duration. In addition, sensitivity to signal duration was greater in rats given prenatal-choline supplementation, particularly at low intensities of both the auditory and visual signals. Overall, these results suggest that prenatal-choline supplementation impacts interval timing by enhancing the differences in temporal integration between auditory and visual stimuli in aged subjects. © 2008 Elsevier B.V. All rights reserved.
Source Title: Brain Research
ISSN: 00068993
DOI: 10.1016/j.brainres.2008.08.062
Appears in Collections:Staff Publications

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