Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2008.08.062
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dc.titlePrenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats
dc.contributor.authorCheng, R.-K.
dc.contributor.authorScott, A.C.
dc.contributor.authorPenney, T.B.
dc.contributor.authorWilliams, C.L.
dc.contributor.authorMeck, W.H.
dc.date.accessioned2016-11-28T10:13:16Z
dc.date.available2016-11-28T10:13:16Z
dc.date.issued2008-10-27
dc.identifier.citationCheng, R.-K., Scott, A.C., Penney, T.B., Williams, C.L., Meck, W.H. (2008-10-27). Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats. Brain Research 1237 : 167-175. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2008.08.062
dc.identifier.issn00068993
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130840
dc.description.abstractCholine supplementation of the maternal diet has a long-term facilitative effect on the interval-timing ability and temporal memory of the offspring. Here, we examined whether prenatal-choline supplementation has modality-specific effects on duration discrimination in aged (20 mo) male rats. Adult offspring of rats that were given sufficient choline in their chow (CON: 1.1 g/kg) or supplemental choline added to their drinking water (SUP: 3.5 g/kg) during embryonic days (ED) 12-17 were trained and tested on a two-modality (auditory and visual signals) duration bisection procedure (2 s vs. 8 s). Intensity (high vs. low) of the auditory and visual timing signals was systematically manipulated across test sessions such that all combinations of signal intensity by modality were tested. Psychometric response functions indicated that prenatal-choline supplementation systematically increased sensitivity to auditory signals relative to visual signals, thereby magnifying the modality effect that sounds are judged to be longer than lights of equivalent duration. In addition, sensitivity to signal duration was greater in rats given prenatal-choline supplementation, particularly at low intensities of both the auditory and visual signals. Overall, these results suggest that prenatal-choline supplementation impacts interval timing by enhancing the differences in temporal integration between auditory and visual stimuli in aged subjects. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.brainres.2008.08.062
dc.sourceScopus
dc.subjectAttention
dc.subjectClock speed
dc.subjectCognitive aging
dc.subjectInterval timing
dc.subjectModality differences
dc.subjectNeural development
dc.subjectPrefrontal cortex
dc.subjectPrenatal nutrition
dc.subjectStimulus intensity
dc.subjectStriatum
dc.subjectTime perception
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.description.doi10.1016/j.brainres.2008.08.062
dc.description.sourcetitleBrain Research
dc.description.volume1237
dc.description.page167-175
dc.description.codenBRREA
dc.identifier.isiut000260815600018
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