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Title: Update on drug-eluting stents for prevention of restenosis
Authors: Lee, C.-H. 
Tan, H.-C. 
Lim, Y.-T. 
Issue Date: Feb-2006
Citation: Lee, C.-H., Tan, H.-C., Lim, Y.-T. (2006-02). Update on drug-eluting stents for prevention of restenosis. Asian Cardiovascular and Thoracic Annals 14 (1) : 75-82. ScholarBank@NUS Repository.
Abstract: Despite the success of coronary stent implantations in the last decade, in-stent restenosis due to neointimal hyperplasia remains a problem to overcome. Neointimal hyperplasia is a vascular response to stent injury and mainly consists of proliferation of smooth muscle cells and deposition of extracellular matrix. Recently, local drug delivery has been advocated as a potential strategy to prevent in-stent restenosis. Unprecedented results have been obtained in early clinical studies on sirolimus-eluting and paclitaxel-eluting stents. Trials using various pharmaceutical coatings on different coronary stents are ongoing. More types of drug-eluting stents are expected on the market in the near future. Meanwhile, the evaluation of drug-eluting stents is entering the second phase in which the safety and efficacy in more complex lesion subsets and different clinical presentations are being investigated. Results including cost-benefit analyses are expected to have a tremendous impact on the practice of interventional cardiology in the next decade.
Source Title: Asian Cardiovascular and Thoracic Annals
ISSN: 02184923
Appears in Collections:Staff Publications

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