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|Title:||Update on drug-eluting stents for prevention of restenosis|
|Authors:||Lee, C.-H. |
|Source:||Lee, C.-H., Tan, H.-C., Lim, Y.-T. (2006-02). Update on drug-eluting stents for prevention of restenosis. Asian Cardiovascular and Thoracic Annals 14 (1) : 75-82. ScholarBank@NUS Repository.|
|Abstract:||Despite the success of coronary stent implantations in the last decade, in-stent restenosis due to neointimal hyperplasia remains a problem to overcome. Neointimal hyperplasia is a vascular response to stent injury and mainly consists of proliferation of smooth muscle cells and deposition of extracellular matrix. Recently, local drug delivery has been advocated as a potential strategy to prevent in-stent restenosis. Unprecedented results have been obtained in early clinical studies on sirolimus-eluting and paclitaxel-eluting stents. Trials using various pharmaceutical coatings on different coronary stents are ongoing. More types of drug-eluting stents are expected on the market in the near future. Meanwhile, the evaluation of drug-eluting stents is entering the second phase in which the safety and efficacy in more complex lesion subsets and different clinical presentations are being investigated. Results including cost-benefit analyses are expected to have a tremendous impact on the practice of interventional cardiology in the next decade.|
|Source Title:||Asian Cardiovascular and Thoracic Annals|
|Appears in Collections:||Staff Publications|
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