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Title: Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines
Authors: St John, A.L.
Abraham, S.N. 
Issue Date: Nov-2009
Citation: St John, A.L., Abraham, S.N. (2009-11). Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nature Medicine 15 (11) : 1259-1265. ScholarBank@NUS Repository.
Abstract: We report that infection of draining lymph nodes (DLNs) by Salmonella typhimurium results in the specific downregulation of the homeostatic chemokines CCL21 and CXCL13, which are essential for normal DLN organization and function. Our data reveal that the mechanism of this suppression is dependent on S. typhimurium LPS (sLPS). The decrease in CCL21 expression involves interaction between sLPS and CCL21-producing cells within DLNs, triggering a distinct Toll-like receptor 4 (TLR4)-mediated host signaling response. In this response, suppressor of cytokine signaling-3 (Socs3) is upregulated, which negatively regulates mothers against decapentaplegic homolog-3 (Smad3)-initiated production of CCL21. Disruption of lymph node architecture and cellular trafficking enhances S. typhimurium virulence and could represent a mechanism of immune suppression used by pathogens that primarily target lymphoid tissue. © 2009 Nature America, Inc. All rights reserved.
Source Title: Nature Medicine
ISSN: 10788956
DOI: 10.1038/nm.2036
Appears in Collections:Staff Publications

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