Please use this identifier to cite or link to this item: https://doi.org/10.1159/000247001
Title: A double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional Chinese medicine neuroaid (MLC 601) in enhancing recovery after stroke (TIERS)
Authors: Kong, K.H.
Wee, S.K.
Ng, C.Y.
Chua, K.
Chan, K.F.
Venketasubramanian, N. 
Chen, C. 
Keywords: Clinical trial
Functional recovery
Motor rehabilitation
Neuroaid
Stroke
Issue Date: Oct-2009
Citation: Kong, K.H., Wee, S.K., Ng, C.Y., Chua, K., Chan, K.F., Venketasubramanian, N., Chen, C. (2009-10). A double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional Chinese medicine neuroaid (MLC 601) in enhancing recovery after stroke (TIERS). Cerebrovascular Diseases 28 (5) : 514-521. ScholarBank@NUS Repository. https://doi.org/10.1159/000247001
Abstract: Background and Objective: Previous clinical studies have shown that Neuroaid (MLC 601) may be beneficial in post-stroke rehabilitation. Our aim was to investigate the efficacy of Neuroaid on motor recovery in ischemic stroke patients using rehabilitation endpoints in accordance with the International Conference on Harmonization/Good Clinical Practice guidelines, in order to provide predictive information for further larger trials. Methods:This is a phase II double-blind, placebo-controlled pilot study of 40 subjects admitted with a recent (less than 1 month) ischemic stroke. All subjects were given either Neuroaid or placebo, 4 capsules 3 times a day for 4 weeks. Fugl-Meyer Assessment (FMA), National Institutes of Health Stroke Scale and Functional Independence Measure scores were measured at initiation of the treatment, and at 4 and 8 weeks. Results: None of the outcomes was statistically significant between the two groups. However, FMA scores showed a positive trend for improvement with Neuroaid treatment over time. Subgroup analysis of subjects with posterior circulation infarction and severe stroke both showed a tendency for better recovery. Conclusion: Some positive trends were observed in the Neuroaid group. A larger multicenter trial focusing on severe stroke patients is needed to better evaluate the role of Neuroaid in aiding stroke recovery in rehabilitation. Copyright © 2009 S. Karger AG.
Source Title: Cerebrovascular Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/129779
ISSN: 10159770
DOI: 10.1159/000247001
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