Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2011.05.007
Title: Epigenetic codes of PPARγ in metabolic disease
Authors: Sugii, S. 
Evans, R.M.
Keywords: Adipose tissue
Deacetylases
Demethylases
Epigenome
Histone acetyltransferases
Histone methyltransferases
Obesity-induced insulin resistance
Issue Date: 7-Jul-2011
Citation: Sugii, S., Evans, R.M. (2011-07-07). Epigenetic codes of PPARγ in metabolic disease. FEBS Letters 585 (13) : 2121-2128. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2011.05.007
Abstract: Peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-regulated nuclear hormone receptor, plays critical roles in metabolism and adipogenesis. PPARγ ligands such as thiazolidinediones (TZDs) exert insulin sensitizing and anti-inflammatory effects primarily through action on adipocytes, and are thus widely used to treat metabolic syndrome, especially type II diabetes. A number of PPARγ interacting partners have been identified, many of which are known epigenetic regulators, including enzymes for histone acetylation/deacetylation and histone methylation/demethylation. However, their functional roles in the PPARγ transcriptional pathway are not well defined. Recent advances in ChIP-based and deep sequencing technology are revealing previously underappreciated epigenomic mechanisms and therapeutic potentials of this nuclear receptor pathway. © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/128661
ISSN: 00145793
DOI: 10.1016/j.febslet.2011.05.007
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