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Title: Epithelial ovarian cancer
Authors: Ng, J.S.
Low, J.J.H. 
Ilancheran, A. 
Keywords: congenital anomalies
epithelial ovarian cancer
fertility preservation
intraperitoneal chemotherapy
live births
ovarian cryopreservation
Issue Date: Jun-2012
Citation: Ng, J.S., Low, J.J.H., Ilancheran, A. (2012-06). Epithelial ovarian cancer. Best Practice and Research: Clinical Obstetrics and Gynaecology 26 (3) : 337-345. ScholarBank@NUS Repository.
Abstract: The incidence of epithelial ovarian cancer in women aged 40 years and younger is 3-17%. The management of these women is challenging and requires balancing the need to treat epithelial ovarian cancer adequately and preserving reproductive potential. Fertility-sparing surgery, especially for early stage epithelial ovarian cancer, seems to be associated with equivalent clinical and cancer outcomes while preserving reproductive potential. A complete staging and cytoreductive procedure retaining the uterus, and at least one grossly normal ovary, is the minimum recommended procedure. Adjuvant chemotherapy with a platinum-taxane combination is recommended as clinically indicated, and is associated with better cancer and survival outcomes. Adjuvant treatment does not seem to increase the risk of congenital anomalies in subsequent pregnancies. Targeted therapy and ovarian cryopreservation are largely experimental and cannot be recommended as part of the clinical standard of care. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Best Practice and Research: Clinical Obstetrics and Gynaecology
ISSN: 15216934
DOI: 10.1016/j.bpobgyn.2011.12.005
Appears in Collections:Staff Publications

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