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Title: B cells help alloreactive T cells differentiate into memory T cells
Authors: Ng, Y.-H. 
Oberbarnscheidt, M.H.
Chandramoorthy, H.C.K.
Hoffman, R.
Chalasani, G.
Keywords: B cells
memory and transplantation
T cells
Issue Date: Sep-2010
Citation: Ng, Y.-H., Oberbarnscheidt, M.H., Chandramoorthy, H.C.K., Hoffman, R., Chalasani, G. (2010-09). B cells help alloreactive T cells differentiate into memory T cells. American Journal of Transplantation 10 (9) : 1970-1980. ScholarBank@NUS Repository.
Abstract: B cells are recognized as effector cells in allograft rejection that are dependent upon T cell help to produce alloantibodies causing graft injury. It is not known if B cells can also help T cells differentiate into memory cells in the alloimmune response. We found that in B-cell-deficient hosts, differentiation of alloreactive T cells into effectors was intact whereas their development into memory T cells was impaired. To test if B cell help for T cells was required for their continued differentiation into memory T cells, activated T cells were sorted from alloimmunized mice and transferred either with or without B cells into naïve adoptive hosts. Activated T cells cotransferred with B cells gave rise to more memory T cells than those transferred without B cells and upon recall, mediated accelerated rejection of skin allografts. Cotransfer of B cells led to increased memory T cells by enhancing activated CD4 T-cell proliferation and activated CD8 T-cell survival. These results indicate that B cells help alloreactive T-cell differentiation, proliferation and survival to generate optimal numbers of functional memory T cells. © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons.
Source Title: American Journal of Transplantation
ISSN: 16006135
DOI: 10.1111/j.1600-6143.2010.03223.x
Appears in Collections:Staff Publications

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