Please use this identifier to cite or link to this item:
https://doi.org/10.1111/j.1600-6143.2010.03223.x
DC Field | Value | |
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dc.title | B cells help alloreactive T cells differentiate into memory T cells | |
dc.contributor.author | Ng, Y.-H. | |
dc.contributor.author | Oberbarnscheidt, M.H. | |
dc.contributor.author | Chandramoorthy, H.C.K. | |
dc.contributor.author | Hoffman, R. | |
dc.contributor.author | Chalasani, G. | |
dc.date.accessioned | 2016-09-06T08:41:18Z | |
dc.date.available | 2016-09-06T08:41:18Z | |
dc.date.issued | 2010-09 | |
dc.identifier.citation | Ng, Y.-H., Oberbarnscheidt, M.H., Chandramoorthy, H.C.K., Hoffman, R., Chalasani, G. (2010-09). B cells help alloreactive T cells differentiate into memory T cells. American Journal of Transplantation 10 (9) : 1970-1980. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1600-6143.2010.03223.x | |
dc.identifier.issn | 16006135 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/126787 | |
dc.description.abstract | B cells are recognized as effector cells in allograft rejection that are dependent upon T cell help to produce alloantibodies causing graft injury. It is not known if B cells can also help T cells differentiate into memory cells in the alloimmune response. We found that in B-cell-deficient hosts, differentiation of alloreactive T cells into effectors was intact whereas their development into memory T cells was impaired. To test if B cell help for T cells was required for their continued differentiation into memory T cells, activated T cells were sorted from alloimmunized mice and transferred either with or without B cells into naïve adoptive hosts. Activated T cells cotransferred with B cells gave rise to more memory T cells than those transferred without B cells and upon recall, mediated accelerated rejection of skin allografts. Cotransfer of B cells led to increased memory T cells by enhancing activated CD4 T-cell proliferation and activated CD8 T-cell survival. These results indicate that B cells help alloreactive T-cell differentiation, proliferation and survival to generate optimal numbers of functional memory T cells. © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1600-6143.2010.03223.x | |
dc.source | Scopus | |
dc.subject | B cells | |
dc.subject | memory and transplantation | |
dc.subject | T cells | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1111/j.1600-6143.2010.03223.x | |
dc.description.sourcetitle | American Journal of Transplantation | |
dc.description.volume | 10 | |
dc.description.issue | 9 | |
dc.description.page | 1970-1980 | |
dc.description.coden | AJTMB | |
dc.identifier.isiut | 000281309400005 | |
Appears in Collections: | Staff Publications |
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