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|Title:||A ceramide-centric view of insulin resistance||Authors:||Chavez, J.A.
|Issue Date:||2-May-2012||Citation:||Chavez, J.A., Summers, S.A. (2012-05-02). A ceramide-centric view of insulin resistance. Cell Metabolism 15 (5) : 585-594. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cmet.2012.04.002||Abstract:||The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of physiological processes and as a critical modulator of cellular stress. In this review, we discuss from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases. Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance. © 2012 Elsevier Inc.||Source Title:||Cell Metabolism||URI:||http://scholarbank.nus.edu.sg/handle/10635/126579||ISSN:||15504131||DOI:||10.1016/j.cmet.2012.04.002|
|Appears in Collections:||Staff Publications|
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