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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cmet.2012.04.002
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dc.titleA ceramide-centric view of insulin resistance
dc.contributor.authorChavez, J.A.
dc.contributor.authorSummers, S.A.
dc.date.accessioned2016-09-06T03:01:33Z
dc.date.available2016-09-06T03:01:33Z
dc.date.issued2012-05-02
dc.identifier.citationChavez, J.A., Summers, S.A. (2012-05-02). A ceramide-centric view of insulin resistance. Cell Metabolism 15 (5) : 585-594. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cmet.2012.04.002
dc.identifier.issn15504131
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126579
dc.description.abstractThe recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of physiological processes and as a critical modulator of cellular stress. In this review, we discuss from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases. Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance. © 2012 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cmet.2012.04.002
dc.sourceScopus
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.cmet.2012.04.002
dc.description.sourcetitleCell Metabolism
dc.description.volume15
dc.description.issue5
dc.description.page585-594
dc.identifier.isiut000303694100007
Appears in Collections:Staff Publications

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