Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.immuni.2012.10.019
Title: Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection
Authors: Chan, C.
St. John, A.
Abraham, S. 
Issue Date: 21-Feb-2013
Citation: Chan, C., St. John, A., Abraham, S. (2013-02-21). Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection. Immunity 38 (2) : 349-359. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2012.10.019
Abstract: The lower urinary tract's virtually inevitable exposure to external microbial pathogens warrants efficient tissue-specialized defenses to maintain sterility. The observation that the bladder can become chronically infected in combination with clinical observations that antibody responses after bladder infections are not detectable suggest defects in the formation of adaptive immunity and immunological memory. We have identified a broadly immunosuppressive transcriptional program specific to the bladder, but not the kidney, during infection of the urinary tract that is dependent on tissue-resident mast cells (MCs). This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence. Therefore, in addition to the previously described role of MCs orchestrating the early innate immunity during bladder infection, they subsequently play a tissue-specific immunosuppressive role. These findings may explain the prevalent recurrence of bladder infections and suggest the bladder as a site exhibiting an intrinsic degree of MC-maintained immune privilege. © 2013 Elsevier Inc.
Source Title: Immunity
URI: http://scholarbank.nus.edu.sg/handle/10635/126514
ISSN: 10747613
DOI: 10.1016/j.immuni.2012.10.019
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