Please use this identifier to cite or link to this item: https://doi.org/10.1586/ern.11.148
Title: Intravenous thrombolysis for acute ischemic stroke in Asia
Authors: Sharma, V.K. 
Ng, K.W.P. 
Venketasubramanian, N. 
Teoh, H.L. 
Chan, B.P.L.
Keywords: acute ischemic stroke
Asian
developing countries
thrombolysis
tissue plasminogen activator
Issue Date: Feb-2012
Citation: Sharma, V.K., Ng, K.W.P., Venketasubramanian, N., Teoh, H.L., Chan, B.P.L. (2012-02). Intravenous thrombolysis for acute ischemic stroke in Asia. Expert Review of Neurotherapeutics 12 (2) : 209-217. ScholarBank@NUS Repository. https://doi.org/10.1586/ern.11.148
Abstract: Data regarding thrombolysis for acute ischemic stroke in Asia are scarce and only a small percentage of patients are thrombolysed. Clinical trials that led to the recommended dose of intravenously administered tissue plasminogen activator (IV-tPA) included predominantly Caucasian patients. However, the single-arm case-controlled observational studies in Japanese patients suggested the clinical efficacy and safety of low-dose IV-tPA (0.6 mg/kg bodyweight; maximum 60 mg) comparable with standard dose (0.9 mg/kg bodyweight; maximum 90 mg). There has been no randomized clinical trial for determining the dose, efficacy or safety of IV-tPA in Asia. Accordingly, the dose of IV-tPA in Asia remains controversial. Reduced treatment cost, lower symptomatic intracerebral hemorrhage risk and comparable efficacy encouraged many Asian centers to adopt low-dose or even variable-dose IV-tPA regimens. We present the current status of thrombolysis for acute ischemic stroke in Asia. © 2012 Expert Reviews Ltd.
Source Title: Expert Review of Neurotherapeutics
URI: http://scholarbank.nus.edu.sg/handle/10635/125853
ISSN: 14737175
DOI: 10.1586/ern.11.148
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