Please use this identifier to cite or link to this item:
https://doi.org/10.1038/nm.3056
Title: | Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance | Authors: | Liew, C.W. Boucher, J. Cheong, J.K. Vernochet, C. Koh, H.-J. Mallol, C. Townsend, K. Langin, D. Kawamori, D. Hu, J. Tseng, Y.-H. Hellerstein, M.K. Farmer, S.R. Goodyear, L. Doria, A. Blüher, M. Hsu, S.I.-H. Kulkarni, R.N. |
Issue Date: | Feb-2013 | Citation: | Liew, C.W., Boucher, J., Cheong, J.K., Vernochet, C., Koh, H.-J., Mallol, C., Townsend, K., Langin, D., Kawamori, D., Hu, J., Tseng, Y.-H., Hellerstein, M.K., Farmer, S.R., Goodyear, L., Doria, A., Blüher, M., Hsu, S.I.-H., Kulkarni, R.N. (2013-02). Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nature Medicine 19 (2) : 217-226. ScholarBank@NUS Repository. https://doi.org/10.1038/nm.3056 | Abstract: | Obesity develops as a result of altered energy homeostasis favoring fat storage. Here we describe a new transcription co-regulator for adiposity and energy metabolism, SERTA domain containing 2 (TRIP-Br2, also called SERTAD2). TRIP-Br2-null mice are resistant to obesity and obesity-related insulin resistance. Adipocytes of these knockout mice showed greater stimulated lipolysis secondary to enhanced expression of hormone sensitive lipase (HSL) and β3-adrenergic (Adrb3) receptors. The knockout mice also have higher energy expenditure because of increased adipocyte thermogenesis and oxidative metabolism caused by upregulating key enzymes in their respective processes. Our data show that a cell-cycle transcriptional co-regulator, TRIP-Br2, modulates fat storage through simultaneous regulation of lipolysis, thermogenesis and oxidative metabolism. These data, together with the observation that TRIP-Br2 expression is selectively elevated in visceral fat in obese humans, suggests that this transcriptional co-regulator is a new therapeutic target for counteracting the development of obesity, insulin resistance and hyperlipidemia. © 2013 Nature America, Inc. All rights reserved. | Source Title: | Nature Medicine | URI: | http://scholarbank.nus.edu.sg/handle/10635/124778 | ISSN: | 10788956 | DOI: | 10.1038/nm.3056 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.