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Title: Viral Membrane Channels: Role and Function in the Virus Life Cycle
Authors: Sze, Ching Wooen 
Tan, Yee-Joo 
Keywords: viroporin; cytopathic effect; viral channel
Issue Date: 23-Jun-2015
Publisher: MDPI
Citation: Sze, Ching Wooen, Tan, Yee-Joo (2015-06-23). Viral Membrane Channels: Role and Function in the Virus Life Cycle. Viruses 7 (6) : 3261-3284. ScholarBank@NUS Repository.
Abstract: Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral life cycle, from genome uncoating to viral release. In addition, the ion channel activity of viroporin causes disruption in the cellular ion homeostasis, in particular the calcium ion. Fluctuation in the calcium level triggers the activation of the host defensive programmed cell death pathways as well as the inflammasome, which in turn are being subverted for the viruses’ replication benefits. This review article summarizes recent developments in the functional investigation of viroporins from various viruses and their contributions to viral replication and virulence.
Source Title: Viruses
ISSN: 19994915
DOI: 10.3390/v7062771
Appears in Collections:Staff Publications

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