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https://doi.org/10.1016/j.ijpara.2008.06.001
Title: | Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis | Authors: | Wawrzyniak, I. Roussel, M. Diogon, M. Couloux, A. Texier, C. Tan, K.S.W. Vivarès, C.P. Delbac, F. Wincker, P. El Alaoui, H. |
Keywords: | Blastocystis hominis Circular DNA molecule Iron-hydrogenase MLOs |
Issue Date: | Oct-2008 | Citation: | Wawrzyniak, I., Roussel, M., Diogon, M., Couloux, A., Texier, C., Tan, K.S.W., Vivarès, C.P., Delbac, F., Wincker, P., El Alaoui, H. (2008-10). Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis. International Journal for Parasitology 38 (12) : 1377-1382. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpara.2008.06.001 | Abstract: | Blastocystis hominis is an anaerobic parasite of the human intestinal tract belonging to the Stramenopile group. Using genome sequencing project data, we describe here the complete sequence of a 29,270-bp circular DNA molecule that presents mitochondrial features (such as oxidative phosphorylation complex I subunits) but lacks complexes III, IV and V. Transmission electron microscopy analyses reveal that this molecule, as well as mitochondrial (NADH:ubiquinone oxidoreductase subunit 7 (NAD7), β-succinyl-CoA synthetase (β-SCS)) and hydrogenosomal (pyruvate ferredoxin oxido-reductase (PFOR), iron-hydrogenase) proteins, are located within double-membrane surrounded-compartments known as mitochondria-like organelles (MLOs). As there is no evidence for hydrogen production by this organism, we suggest that MLOs are more likely anaerobic mitochondria. © 2008 Australian Society for Parasitology Inc. | Source Title: | International Journal for Parasitology | URI: | http://scholarbank.nus.edu.sg/handle/10635/120835 | ISSN: | 00207519 | DOI: | 10.1016/j.ijpara.2008.06.001 |
Appears in Collections: | Staff Publications |
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