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Title: Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis
Authors: Wawrzyniak, I.
Roussel, M.
Diogon, M.
Couloux, A.
Texier, C.
Tan, K.S.W. 
Vivarès, C.P.
Delbac, F.
Wincker, P.
El Alaoui, H.
Keywords: Blastocystis hominis
Circular DNA molecule
Issue Date: Oct-2008
Citation: Wawrzyniak, I., Roussel, M., Diogon, M., Couloux, A., Texier, C., Tan, K.S.W., Vivarès, C.P., Delbac, F., Wincker, P., El Alaoui, H. (2008-10). Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis. International Journal for Parasitology 38 (12) : 1377-1382. ScholarBank@NUS Repository.
Abstract: Blastocystis hominis is an anaerobic parasite of the human intestinal tract belonging to the Stramenopile group. Using genome sequencing project data, we describe here the complete sequence of a 29,270-bp circular DNA molecule that presents mitochondrial features (such as oxidative phosphorylation complex I subunits) but lacks complexes III, IV and V. Transmission electron microscopy analyses reveal that this molecule, as well as mitochondrial (NADH:ubiquinone oxidoreductase subunit 7 (NAD7), β-succinyl-CoA synthetase (β-SCS)) and hydrogenosomal (pyruvate ferredoxin oxido-reductase (PFOR), iron-hydrogenase) proteins, are located within double-membrane surrounded-compartments known as mitochondria-like organelles (MLOs). As there is no evidence for hydrogen production by this organism, we suggest that MLOs are more likely anaerobic mitochondria. © 2008 Australian Society for Parasitology Inc.
Source Title: International Journal for Parasitology
ISSN: 00207519
DOI: 10.1016/j.ijpara.2008.06.001
Appears in Collections:Staff Publications

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