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Title: Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?
Authors: Whiteman, M. 
Spencer, J.P.E.
Szeto, H.H.
Armstrong, J.S. 
Issue Date: 1-Mar-2008
Citation: Whiteman, M., Spencer, J.P.E., Szeto, H.H., Armstrong, J.S. (2008-03-01). Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?. Antioxidants and Redox Signaling 10 (3) : 641-650. ScholarBank@NUS Repository.
Abstract: Reactive chlorine species such as hypochlorous acid (HOCl) are cytotoxic oxidants generated by activated neutrophils at the sites of chronic inflammation. Since mitochondria are key mediators of apoptosis and necrosis, we hypothesized that mitochondriotropic antioxidants could limit HOCl-mediated intracellular oxidative injury to human fetal liver cells, preserve mitochondrial function, and prevent cell death. In this current study, we show that recently developed mitochondria-targeted antioxidants (MitoQ and SS31) significantly protected against HOCl-induced mitochondrial damage and cell death at concentrations ≥25 nM. Our study highlights the potential application of mitochondria-specific targeted antioxidants for the prevention of cellular dysfunction and cell death under conditions of chlorinative stress, as occurs during chronic inflammation. © 2008 Mary Ann Liebert, Inc.
Source Title: Antioxidants and Redox Signaling
ISSN: 15230864
DOI: 10.1089/ars.2007.1879
Appears in Collections:Staff Publications

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