Please use this identifier to cite or link to this item: https://doi.org/10.1089/ars.2007.1879
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dc.titleDo mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?
dc.contributor.authorWhiteman, M.
dc.contributor.authorSpencer, J.P.E.
dc.contributor.authorSzeto, H.H.
dc.contributor.authorArmstrong, J.S.
dc.date.accessioned2015-09-10T03:33:19Z
dc.date.available2015-09-10T03:33:19Z
dc.date.issued2008-03-01
dc.identifier.citationWhiteman, M., Spencer, J.P.E., Szeto, H.H., Armstrong, J.S. (2008-03-01). Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?. Antioxidants and Redox Signaling 10 (3) : 641-650. ScholarBank@NUS Repository. https://doi.org/10.1089/ars.2007.1879
dc.identifier.issn15230864
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120818
dc.description.abstractReactive chlorine species such as hypochlorous acid (HOCl) are cytotoxic oxidants generated by activated neutrophils at the sites of chronic inflammation. Since mitochondria are key mediators of apoptosis and necrosis, we hypothesized that mitochondriotropic antioxidants could limit HOCl-mediated intracellular oxidative injury to human fetal liver cells, preserve mitochondrial function, and prevent cell death. In this current study, we show that recently developed mitochondria-targeted antioxidants (MitoQ and SS31) significantly protected against HOCl-induced mitochondrial damage and cell death at concentrations ≥25 nM. Our study highlights the potential application of mitochondria-specific targeted antioxidants for the prevention of cellular dysfunction and cell death under conditions of chlorinative stress, as occurs during chronic inflammation. © 2008 Mary Ann Liebert, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1089/ars.2007.1879
dc.sourceScopus
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1089/ars.2007.1879
dc.description.sourcetitleAntioxidants and Redox Signaling
dc.description.volume10
dc.description.issue3
dc.description.page641-650
dc.description.codenARSIF
dc.identifier.isiut000252559700013
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