Please use this identifier to cite or link to this item:
https://doi.org/10.1002/jcb.22913
Title: | PRL-3 phosphatase and cancer metastasis | Authors: | Al-Aidaroos, A.Q.O. Zeng, Q. |
Keywords: | cancer cell signaling cancer metastasis PRL-3 phosphatase |
Issue Date: | 1-Dec-2010 | Citation: | Al-Aidaroos, A.Q.O., Zeng, Q. (2010-12-01). PRL-3 phosphatase and cancer metastasis. Journal of Cellular Biochemistry 111 (5) : 1087-1098. ScholarBank@NUS Repository. https://doi.org/10.1002/jcb.22913 | Abstract: | The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. © 2010 Wiley-Liss, Inc. | Source Title: | Journal of Cellular Biochemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/117355 | ISSN: | 07302312 | DOI: | 10.1002/jcb.22913 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
104
checked on May 20, 2022
WEB OF SCIENCETM
Citations
100
checked on May 20, 2022
Page view(s)
170
checked on May 12, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.