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|Title:||PRL-3 phosphatase and cancer metastasis|
|Keywords:||cancer cell signaling|
|Source:||Al-Aidaroos, A.Q.O., Zeng, Q. (2010-12-01). PRL-3 phosphatase and cancer metastasis. Journal of Cellular Biochemistry 111 (5) : 1087-1098. ScholarBank@NUS Repository. https://doi.org/10.1002/jcb.22913|
|Abstract:||The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. © 2010 Wiley-Liss, Inc.|
|Source Title:||Journal of Cellular Biochemistry|
|Appears in Collections:||Staff Publications|
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