Please use this identifier to cite or link to this item:
|Title:||The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers||Authors:||Subramaniam, M.M.
|Issue Date:||Feb-2014||Citation:||Subramaniam, M.M., Loh, M., Chan, J.Y., Liem, N., Lim, P.L., Peng, Y.W., Lim, X.Y., Yeoh, K.G., Iacopetta, B., Soong, R., Salto-Tellez, M. (2014-02). The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers. Molecular Carcinogenesis 53 (2) : 98-108. ScholarBank@NUS Repository. https://doi.org/10.1002/mc.21951||Abstract:||The degree of gene hypermethylation in non-neoplastic colonic mucosa (NNCM) is a potentially important event in the development of colorectal cancer (CRC), particularly for the subgroup with a CpG island methylator phenotype (CIMP). In this study, we aimed to use an unbiased and high-throughput approach to evaluate the topography of DNA methylation in the non-neoplastic colonic mucosa (NNCM) surrounding colorectal cancer (CRC). A total of 61 tissue samples comprising 53 NNCM and 8 tumor samples were obtained from hemicolectomy specimens of two CRC patients (Cases 1 and 2). NNCM was stripped from the underlying colonic wall and samples taken at varying distances from the tumor. The level of DNA methylation in NNCM and tumor tissues was assessed at 1,505 CpG sites in 807 cancer-related genes using Illumina GoldenGate® methylation arrays. Case 1 tumor showed significantly higher levels of methylation compared to surrounding NNCM samples (P||Source Title:||Molecular Carcinogenesis||URI:||http://scholarbank.nus.edu.sg/handle/10635/116648||ISSN:||08991987||DOI:||10.1002/mc.21951|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 25, 2021
WEB OF SCIENCETM
checked on Feb 17, 2021
checked on Feb 13, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.