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Please use this identifier to cite or link to this item: https://doi.org/10.1002/mc.21951
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dc.titleThe topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers
dc.contributor.authorSubramaniam, M.M.
dc.contributor.authorLoh, M.
dc.contributor.authorChan, J.Y.
dc.contributor.authorLiem, N.
dc.contributor.authorLim, P.L.
dc.contributor.authorPeng, Y.W.
dc.contributor.authorLim, X.Y.
dc.contributor.authorYeoh, K.G.
dc.contributor.authorIacopetta, B.
dc.contributor.authorSoong, R.
dc.contributor.authorSalto-Tellez, M.
dc.date.accessioned2014-12-12T07:52:27Z
dc.date.available2014-12-12T07:52:27Z
dc.date.issued2014-02
dc.identifier.citationSubramaniam, M.M., Loh, M., Chan, J.Y., Liem, N., Lim, P.L., Peng, Y.W., Lim, X.Y., Yeoh, K.G., Iacopetta, B., Soong, R., Salto-Tellez, M. (2014-02). The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers. Molecular Carcinogenesis 53 (2) : 98-108. ScholarBank@NUS Repository. https://doi.org/10.1002/mc.21951
dc.identifier.issn08991987
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116648
dc.description.abstractThe degree of gene hypermethylation in non-neoplastic colonic mucosa (NNCM) is a potentially important event in the development of colorectal cancer (CRC), particularly for the subgroup with a CpG island methylator phenotype (CIMP). In this study, we aimed to use an unbiased and high-throughput approach to evaluate the topography of DNA methylation in the non-neoplastic colonic mucosa (NNCM) surrounding colorectal cancer (CRC). A total of 61 tissue samples comprising 53 NNCM and 8 tumor samples were obtained from hemicolectomy specimens of two CRC patients (Cases 1 and 2). NNCM was stripped from the underlying colonic wall and samples taken at varying distances from the tumor. The level of DNA methylation in NNCM and tumor tissues was assessed at 1,505 CpG sites in 807 cancer-related genes using Illumina GoldenGate® methylation arrays. Case 1 tumor showed significantly higher levels of methylation compared to surrounding NNCM samples (P
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/mc.21951
dc.sourceScopus
dc.subjectColorectal cancer
dc.subjectColorectal field
dc.subjectDNA methylation
dc.subjectField effect
dc.subjectNon-neoplastic mucosa
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1002/mc.21951
dc.description.sourcetitleMolecular Carcinogenesis
dc.description.volume53
dc.description.issue2
dc.description.page98-108
dc.description.codenMOCAE
dc.identifier.isiut000329926900002
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