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https://doi.org/10.1002/ijc.27964
| Title: | RUNX family: Regulation and diversification of roles through interacting proteins | Authors: | Chuang, L.S.H. Ito, K. Ito, Y. |
Keywords: | interacting proteins post-translational modification RUNX signaling pathways tumor suppressor |
Issue Date: | 15-Mar-2013 | Citation: | Chuang, L.S.H., Ito, K., Ito, Y. (2013-03-15). RUNX family: Regulation and diversification of roles through interacting proteins. International Journal of Cancer 132 (6) : 1260-1271. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.27964 | Abstract: | The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses. Copyright © 2012 UICC. | Source Title: | International Journal of Cancer | URI: | http://scholarbank.nus.edu.sg/handle/10635/116578 | ISSN: | 00207136 | DOI: | 10.1002/ijc.27964 |
| Appears in Collections: | Staff Publications |
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