Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.27964
Title: RUNX family: Regulation and diversification of roles through interacting proteins
Authors: Chuang, L.S.H. 
Ito, K.
Ito, Y.
Keywords: interacting proteins
post-translational modification
RUNX
signaling pathways
tumor suppressor
Issue Date: 15-Mar-2013
Citation: Chuang, L.S.H., Ito, K., Ito, Y. (2013-03-15). RUNX family: Regulation and diversification of roles through interacting proteins. International Journal of Cancer 132 (6) : 1260-1271. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.27964
Abstract: The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses. Copyright © 2012 UICC.
Source Title: International Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/116578
ISSN: 00207136
DOI: 10.1002/ijc.27964
Appears in Collections:Staff Publications

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