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Title: Loperamide-based compounds as additives for biofouling management
Authors: Chai, C.L.L.
Teo, S.L.M. 
Jameson, F.K.M.
Lee, S.S.C. 
Likhitsup, A.
Chen, C.-L. 
Rittschof, D. 
Keywords: Amides
Issue Date: Apr-2014
Citation: Chai, C.L.L., Teo, S.L.M., Jameson, F.K.M., Lee, S.S.C., Likhitsup, A., Chen, C.-L., Rittschof, D. (2014-04). Loperamide-based compounds as additives for biofouling management. International Biodeterioration and Biodegradation 89 : 82-87. ScholarBank@NUS Repository.
Abstract: The commercial pharmaceutical Imodium™, which contains the active ingredient loperamide hydrochloride, has been shown to have biofouling control properties. However, due to concerns associated with safety and persistence of this active pharmaceutical ingredient (API) in the environment, the development of loperamide as an anti-fouling additive is not desirable. In this paper, we report our efforts directed towards the design and synthesis of small molecule anti-foulants using the loperamide parent compound as the lead compound. These loperamide-based compounds can be synthesized readily and inexpensively. Several of the compounds identified are potentially useful as additives in marine antifouling coatings as they control attachment of barnacles in laboratory tests and an estimation program (BIOWIN) developed by the US Environmental Protection Agency predicts that they will degrade completely in weeks to months. © 2014 Elsevier Ltd.
Source Title: International Biodeterioration and Biodegradation
ISSN: 09648305
DOI: 10.1016/j.ibiod.2014.01.003
Appears in Collections:Staff Publications

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