Please use this identifier to cite or link to this item:
|Title:||Runx family genes, niche, and stem cell quiescence||Authors:||Wang, C.Q.
Stem cell exhaustion
|Issue Date:||Apr-2010||Citation:||Wang, C.Q., Jacob, B., Nah, G.S.S., Osato, M. (2010-04). Runx family genes, niche, and stem cell quiescence. Blood Cells, Molecules, and Diseases 44 (4) : 275-286. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bcmd.2010.01.006||Abstract:||In multicellular organisms, terminally differentiated cells of most tissues are short-lived and therefore require constant replenishment from rapidly dividing stem cells for homeostasis and tissue repair. For the stem cells to last throughout the lifetime of the organism, however, a small subset of stem cells, which are maintained in a hibernation-like state known as stem cell quiescence, is required. Such dormant stem cells reside in the niche and are activated into proliferation only when necessary. A multitude of factors are required for the maintenance of stem cell quiescence and niche. In particular, the Runx family genes have been implicated in stem cell quiescence in various organisms and tissues. In this review, we discuss the maintenance of stem cell quiescence in various tissues, mainly in the context of the Runx family genes, and with special focus on the hematopoietic system. © 2010 Elsevier Inc.||Source Title:||Blood Cells, Molecules, and Diseases||URI:||http://scholarbank.nus.edu.sg/handle/10635/115921||ISSN:||10799796||DOI:||10.1016/j.bcmd.2010.01.006|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 12, 2019
WEB OF SCIENCETM
checked on Jul 3, 2019
checked on Aug 16, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.