Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bcmd.2010.01.006
Title: Runx family genes, niche, and stem cell quiescence
Authors: Wang, C.Q.
Jacob, B. 
Nah, G.S.S.
Osato, M. 
Keywords: AML1
Bmi-1
CXCR4
G0 phase
Stem cell exhaustion
Issue Date: Apr-2010
Citation: Wang, C.Q., Jacob, B., Nah, G.S.S., Osato, M. (2010-04). Runx family genes, niche, and stem cell quiescence. Blood Cells, Molecules, and Diseases 44 (4) : 275-286. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bcmd.2010.01.006
Abstract: In multicellular organisms, terminally differentiated cells of most tissues are short-lived and therefore require constant replenishment from rapidly dividing stem cells for homeostasis and tissue repair. For the stem cells to last throughout the lifetime of the organism, however, a small subset of stem cells, which are maintained in a hibernation-like state known as stem cell quiescence, is required. Such dormant stem cells reside in the niche and are activated into proliferation only when necessary. A multitude of factors are required for the maintenance of stem cell quiescence and niche. In particular, the Runx family genes have been implicated in stem cell quiescence in various organisms and tissues. In this review, we discuss the maintenance of stem cell quiescence in various tissues, mainly in the context of the Runx family genes, and with special focus on the hematopoietic system. © 2010 Elsevier Inc.
Source Title: Blood Cells, Molecules, and Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/115921
ISSN: 10799796
DOI: 10.1016/j.bcmd.2010.01.006
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