Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10689-008-9209-5
Title: Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore
Authors: Yap, H.-L. 
Chieng, W.-S.
Lim, J.R.-C.
Lim, R.S.-C.
Soo, R. 
Guo, J. 
Lee, S.-C. 
Keywords: Asia
Cancer genetics
Chinese
Hereditary non-polyposis colorectal cancer
Lynch syndrome
MLH1
MSH2
Recurring mutation
Singapore
Issue Date: Jun-2009
Citation: Yap, H.-L., Chieng, W.-S., Lim, J.R.-C., Lim, R.S.-C., Soo, R., Guo, J., Lee, S.-C. (2009-06). Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore. Familial Cancer 8 (2) : 85-94. ScholarBank@NUS Repository. https://doi.org/10.1007/s10689-008-9209-5
Abstract: Lynch syndrome is an autosomal dominant disorder due to mutations in DNA mismatch repair genes, causing young onset colorectal cancer and extra-colonic cancers such as endometrial and stomach cancers. We genotyped MLH1 and MSH2 in patients suspected to have Lynch syndrome and correlated patient clinical characteristics and family history with deleterious mutations. Eighty-five unrelated patients participated. Comprehensive sequencing was performed for MLH1 and MSH2, including all coding regions, splice-site junctions and promoter regions. Of the 29 different mutations found, 11 were deleterious, of which 10 were in MLH1 and 1 in MSH2. Three recurring MLH1 deleterious mutations were found in two unrelated Chinese patients each, and haplotype analysis suggested common ancestral origin for the recurring mutations and possible founder effect. Families with clinical diagnosis of HNPCC (i.e. family history which fulfills the Amsterdam I/II criteria) was the strongest predictor for finding a deleterious mutation, and stomach cancer was the most commonly reported extra-colonic cancer in families found with a deleterious MLH1 or MSH2 mutation. The observation of recurring deleterious MLH1 mutations in our study suggests possible founder effect and may have implications on genetic testing in Asia. © 2008 Springer Science+Business Media B.V.
Source Title: Familial Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/115902
ISSN: 13899600
DOI: 10.1007/s10689-008-9209-5
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Aug 21, 2019

WEB OF SCIENCETM
Citations

14
checked on Aug 21, 2019

Page view(s)

60
checked on Aug 16, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.