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Title: Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer
Authors: Hui, K.M. 
Sabapathy, T.K. 
Oei, A.A. 
Chia, T.F. 
Keywords: Allogeneic
Cytotoxic T lymphocyte
Gene gun
Genetic immunization
Issue Date: 16-May-1994
Citation: Hui, K.M.,Sabapathy, T.K.,Oei, A.A.,Chia, T.F. (1994-05-16). Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer. Journal of Immunological Methods 171 (2) : 147-155. ScholarBank@NUS Repository.
Abstract: Mature T lymphocytes comprise functionally distinct subsets with discrete roles in the regulation of the immune response. The celluar basis of the anti-tumor effect is now understood to involve the activation and expansion of tumor-specific cytotoxic T lymphocytes (CTL). To immuno-potentiate the generation of CTL, we have employed the biolistic system for the genetic immunization of mice. Here, we report the efficient generation of anti-H-2Kb allo-reactive CTL by particle acceleration-mediated genetic immunization of mouse spleen cells with H-2Kb DNA. The insertion and expression of exogeneous gene into host spleen cells following in situ genetic inoculation to effect the generation of a cellular immune response may permit novel alternative strategies for immunotherapy. © 1994.
Source Title: Journal of Immunological Methods
ISSN: 00221759
Appears in Collections:Staff Publications

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