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|Title:||Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer|
|Authors:||Hui, K.M. |
Cytotoxic T lymphocyte
|Citation:||Hui, K.M.,Sabapathy, T.K.,Oei, A.A.,Chia, T.F. (1994-05-16). Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer. Journal of Immunological Methods 171 (2) : 147-155. ScholarBank@NUS Repository.|
|Abstract:||Mature T lymphocytes comprise functionally distinct subsets with discrete roles in the regulation of the immune response. The celluar basis of the anti-tumor effect is now understood to involve the activation and expansion of tumor-specific cytotoxic T lymphocytes (CTL). To immuno-potentiate the generation of CTL, we have employed the biolistic system for the genetic immunization of mice. Here, we report the efficient generation of anti-H-2Kb allo-reactive CTL by particle acceleration-mediated genetic immunization of mouse spleen cells with H-2Kb DNA. The insertion and expression of exogeneous gene into host spleen cells following in situ genetic inoculation to effect the generation of a cellular immune response may permit novel alternative strategies for immunotherapy. © 1994.|
|Source Title:||Journal of Immunological Methods|
|Appears in Collections:||Staff Publications|
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