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Title: A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Authors: Manser, E. 
Leung, T. 
Salihuddin, H.
Zhao, Z.-S. 
Lim, L.
Issue Date: 6-Jan-1994
Citation: Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., Lim, L. (1994-01-06). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367 (6458) : 40-46. ScholarBank@NUS Repository.
Abstract: A new brain serine/threonine protein kinase may be a target for the p21(ras)-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.
Source Title: Nature
ISSN: 00280836
DOI: 10.1038/367040a0
Appears in Collections:Staff Publications

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