A brain serine/threonine protein kinase activated by Cdc42 and Rac1

Please use this identifier to cite or link to this item: https://doi.org/10.1038/367040a0

Title:	A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Authors:	Manser, E. Leung, T. Salihuddin, H. Zhao, Z.-S. Lim, L.
Issue Date:	6-Jan-1994
Citation:	Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., Lim, L. (1994-01-06). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367 (6458) : 40-46. ScholarBank@NUS Repository. https://doi.org/10.1038/367040a0
Abstract:	A new brain serine/threonine protein kinase may be a target for the p21(ras)-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.
Source Title:	Nature
URI:	http://scholarbank.nus.edu.sg/handle/10635/115554
ISSN:	00280836
DOI:	10.1038/367040a0
Appears in Collections:	Staff Publications

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