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Please use this identifier to cite or link to this item: https://doi.org/10.1038/367040a0
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dc.titleA brain serine/threonine protein kinase activated by Cdc42 and Rac1
dc.contributor.authorManser, E.
dc.contributor.authorLeung, T.
dc.contributor.authorSalihuddin, H.
dc.contributor.authorZhao, Z.-S.
dc.contributor.authorLim, L.
dc.date.accessioned2014-12-12T07:29:21Z
dc.date.available2014-12-12T07:29:21Z
dc.date.issued1994-01-06
dc.identifier.citationManser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., Lim, L. (1994-01-06). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367 (6458) : 40-46. ScholarBank@NUS Repository. https://doi.org/10.1038/367040a0
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115554
dc.description.abstractA new brain serine/threonine protein kinase may be a target for the p21(ras)-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/367040a0
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1038/367040a0
dc.description.sourcetitleNature
dc.description.volume367
dc.description.issue6458
dc.description.page40-46
dc.description.codenNATUA
dc.identifier.isiutA1994MP86500051
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