Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2012.03.067
Title: α-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells
Authors: Yu, H.
Li, Z. 
Ghosh, D.
Lim, T.K. 
He, Y. 
Lin, Q. 
Keywords: ACTN4
Calmodulin-like domain
Fshβ
GnRH
Nuclear translocation
Issue Date: 21-May-2012
Citation: Yu, H., Li, Z., Ghosh, D., Lim, T.K., He, Y., Lin, Q. (2012-05-21). α-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells. FEBS Letters 586 (10) : 1466-1471. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2012.03.067
Abstract: Gonadotropin-releasing hormone (GnRH) regulates the synthesis and secretion of follicle-stimulating hormone (FSH) by stimulating the transcription of Fshβ gene. Our iTRAQ quantitative proteomics result showed that the abundance of α-actinin4 (ACTN4) increased in the nuclei of LβT2 cells upon GnRH induction. Using RNA interference, reverse transcription and real-time PCR, luciferase and transient transfection assays, we proved that ACTN4 is involved in the regulation of mouse Fshβ gene (mFshβ) transcription and its C-terminal calmodulin (CaM)-like domain is crucial for this process. Our study suggests that ACTN4 nuclear translocation mediates GnRH stimulation of mFshβ gene transcription. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/115360
ISSN: 00145793
DOI: 10.1016/j.febslet.2012.03.067
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