Please use this identifier to cite or link to this item:
|Title:||α-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells||Authors:||Yu, H.
|Issue Date:||21-May-2012||Citation:||Yu, H., Li, Z., Ghosh, D., Lim, T.K., He, Y., Lin, Q. (2012-05-21). α-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells. FEBS Letters 586 (10) : 1466-1471. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2012.03.067||Abstract:||Gonadotropin-releasing hormone (GnRH) regulates the synthesis and secretion of follicle-stimulating hormone (FSH) by stimulating the transcription of Fshβ gene. Our iTRAQ quantitative proteomics result showed that the abundance of α-actinin4 (ACTN4) increased in the nuclei of LβT2 cells upon GnRH induction. Using RNA interference, reverse transcription and real-time PCR, luciferase and transient transfection assays, we proved that ACTN4 is involved in the regulation of mouse Fshβ gene (mFshβ) transcription and its C-terminal calmodulin (CaM)-like domain is crucial for this process. Our study suggests that ACTN4 nuclear translocation mediates GnRH stimulation of mFshβ gene transcription. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/115360||ISSN:||00145793||DOI:||10.1016/j.febslet.2012.03.067|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 23, 2019
WEB OF SCIENCETM
checked on Aug 14, 2019
checked on Aug 16, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.