Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2012.03.067
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dc.titleα-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells
dc.contributor.authorYu, H.
dc.contributor.authorLi, Z.
dc.contributor.authorGhosh, D.
dc.contributor.authorLim, T.K.
dc.contributor.authorHe, Y.
dc.contributor.authorLin, Q.
dc.date.accessioned2014-12-12T07:14:36Z
dc.date.available2014-12-12T07:14:36Z
dc.date.issued2012-05-21
dc.identifier.citationYu, H., Li, Z., Ghosh, D., Lim, T.K., He, Y., Lin, Q. (2012-05-21). α-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone β-subunit gene transcription in LβT2 cells. FEBS Letters 586 (10) : 1466-1471. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2012.03.067
dc.identifier.issn00145793
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115360
dc.description.abstractGonadotropin-releasing hormone (GnRH) regulates the synthesis and secretion of follicle-stimulating hormone (FSH) by stimulating the transcription of Fshβ gene. Our iTRAQ quantitative proteomics result showed that the abundance of α-actinin4 (ACTN4) increased in the nuclei of LβT2 cells upon GnRH induction. Using RNA interference, reverse transcription and real-time PCR, luciferase and transient transfection assays, we proved that ACTN4 is involved in the regulation of mouse Fshβ gene (mFshβ) transcription and its C-terminal calmodulin (CaM)-like domain is crucial for this process. Our study suggests that ACTN4 nuclear translocation mediates GnRH stimulation of mFshβ gene transcription. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.febslet.2012.03.067
dc.sourceScopus
dc.subjectACTN4
dc.subjectCalmodulin-like domain
dc.subjectFshβ
dc.subjectGnRH
dc.subjectNuclear translocation
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentNUS ENVIRONMENTAL RESEARCH INSTITUTE
dc.description.doi10.1016/j.febslet.2012.03.067
dc.description.sourcetitleFEBS Letters
dc.description.volume586
dc.description.issue10
dc.description.page1466-1471
dc.description.codenFEBLA
dc.identifier.isiut000304104200013
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