The slow-releasing Hydrogen Sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo

Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0021077

Title:	The slow-releasing Hydrogen Sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo
Authors:	Lee, Z.W. Zhou, J. Chen, C.-S. Zhao, Y. Tan, C.-H. Li, L. Moore, P.K. Deng, L.-W.
Issue Date:	2011
Citation:	Lee, Z.W., Zhou, J., Chen, C.-S., Zhao, Y., Tan, C.-H., Li, L., Moore, P.K., Deng, L.-W. (2011). The slow-releasing Hydrogen Sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS ONE 6 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0021077
Abstract:	The slow-releasing hydrogen sulfide (H2S) donor, GYY4137, caused concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38) as determined by trypan blue exclusion. Sodium hydrosulfide (NaHS) was less potent and not active in all cell lines. A structural analogue of GYY4137 (ZYJ1122) lacking sulfur and thence not able to release H2S was inactive. Similar results were obtained using a clonogenic assay. Incubation of GYY4137 (400 μM) in culture medium led to the generation of low (
Source Title:	PLoS ONE
URI:	http://scholarbank.nus.edu.sg/handle/10635/115330
ISSN:	19326203
DOI:	10.1371/journal.pone.0021077
Appears in Collections:	Staff Publications Elements

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