Please use this identifier to cite or link to this item: https://doi.org/10.1142/S0192415X06003928
Title: Clinical and molecular evaluation of warming and tonic herb treatment for sibling patients of a typical kidney-yang deficiency family
Authors: Pan, L.
Wang, M.
Wang, J.G. 
Wu, B.
Hui, K.M.
Keywords: Accumulated clinical scores
cDNA microarray
Differentially gene expression
Family study
Kidney-yang deficiency
Therapeutic efficacy
Warming and tonic herb treatment
Issue Date: 2006
Citation: Pan, L., Wang, M., Wang, J.G., Wu, B., Hui, K.M. (2006). Clinical and molecular evaluation of warming and tonic herb treatment for sibling patients of a typical kidney-yang deficiency family. American Journal of Chinese Medicine 34 (3) : 387-400. ScholarBank@NUS Repository. https://doi.org/10.1142/S0192415X06003928
Abstract: It is essential to explore the molecular therapeutic effect of warm and tonic herb treatment for individuals with typical kidney-yang deficiency. In this report, we have identified members of a family with a history of suffering from cold and kidney-yang deficiency syndromes. First, we have employed the accumulated scores of the 40-items clinical scoring indicators for kidney-yang deficiency and cold syndromes to clinically assess the presence or absence of the deficiency for 15 family members. We then proceeded to compare the gene expression profiles of RNA isolated from blood samples, prior to and post-herbal treatment, of a sibling (brother and younger sister) that are suffering from the deficiency using cDNA microarrays with 18816 genes. Following treatments with the warming and tonic herb, the accumulated clinical scores obtained from the 40-items clinical scoring indicators were compared to those obtained pre-treatment. It was observed that the accumulated clinical scores were reduced by 1/3 for the brother and 2/3 for his younger sister following the treatments. Furthermore, we have demonstrated that the level of gene expression for a total of 33 genes at pre-treatment was modulated after treatments with the warming and tonic herb and correlated well with the clinical improvements of their syndromes. These results suggest that the combination of gene profiling and the accumulated clinical scores obtained from the 40-items clinical scoring indicators may provide an accurate clinical assessment and a way to monitor the therapeutic efficacy of the warming and tonic herb treatment. © 2006 World Scientific Publishing Company.
Source Title: American Journal of Chinese Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/115028
ISSN: 0192415X
DOI: 10.1142/S0192415X06003928
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Jun 16, 2021

WEB OF SCIENCETM
Citations

13
checked on Jun 7, 2021

Page view(s)

81
checked on Jun 7, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.