Please use this identifier to cite or link to this item: https://doi.org/10.2217/14622416.6.8.835
Title: Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
Authors: Soong, R. 
Diasio, R.B.
Keywords: 5-fluorouracil
Capecitabine
Dihydropyrimdine dehydrogenase
Methylene tetrahydrofolate reductase
Microsatellite instability
p53
S1
Tegafur
Thymidine phosphorylase
Thymidylate synthase
Issue Date: Dec-2005
Citation: Soong, R., Diasio, R.B. (2005-12). Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics. Pharmacogenomics 6 (8) : 835-847. ScholarBank@NUS Repository. https://doi.org/10.2217/14622416.6.8.835
Abstract: In cancer pharmacogenetics (the study of how variability in a single or set of known genes influences drug response) and pharmacogenomics (the study of variability on a genome-wide scale), one of the most important fields of research focuses on the fluoropyrimdines (FPs) and, in particular, 5-fluorouracil (5-FU). After over 40 years of use, FPs remain one of the most commonly used cancer chemotherapy agents and their application includes a wide spectrum of cancer types. FPs also continue to be the baseline component for many new regimens with novel molecular-targeted agents that are being rapidly introduced. Hence, it would seem appropriate that pharmacogenetic/genomic models for optimizing cancer patient management would involve indicators of FP response. In this article, the current trends in FP pharmacogenetics and pharmacogenomics are reviewed based on the advances made to date and the challenges faced in realizing their full potential. © 2005 Future Medicine Ltd.
Source Title: Pharmacogenomics
URI: http://scholarbank.nus.edu.sg/handle/10635/113776
ISSN: 14622416
DOI: 10.2217/14622416.6.8.835
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

26
checked on Oct 27, 2020

WEB OF SCIENCETM
Citations

26
checked on Oct 20, 2020

Page view(s)

84
checked on Oct 23, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.