Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113667
Title: Tardive dyskinesia is not associated with the serotonin gene polymorphism (5-HTTLPR) in Chinese
Authors: Chong, S.-A.
Tan, E.-C.
Tan, C.-H.
Mahendren, R.
Tay, A.H.-N. 
Chua, H.-C.
Keywords: Chinese
Schizophrenia
Serotonin transporter promoter
Tardive dyskinesia
Issue Date: 4-Dec-2000
Citation: Chong, S.-A.,Tan, E.-C.,Tan, C.-H.,Mahendren, R.,Tay, A.H.-N.,Chua, H.-C. (2000-12-04). Tardive dyskinesia is not associated with the serotonin gene polymorphism (5-HTTLPR) in Chinese. American Journal of Medical Genetics - Neuropsychiatric Genetics 96 (6) : 712-715. ScholarBank@NUS Repository.
Abstract: Neuroleptics are the mainstay of treatment for schizophrenia, but one of the complications is the development of tardive dyskinesia (TD). The pathophysiology of TD may involve dopamine-serotonin interaction. The serotonin transporter participates in the reuptake and termination of serotonin neurotransmission, and the gene that codes for this protein is thus a candidate gene for the development of TD. There is a functional polymorphism in the transcriptional control region of the serotonin transporter gene, and we investigated the association between this polymorphism and TD in Chinese schizophrenic patients. The patients who did not differ in age and sex distribution did not show variation on the rates of TD and Abnormal Involuntary Movements Scale (AIMS) scores with genotypes. Our findings suggest that 5-HTTLPR polymorphism is not a risk factor for TD in Chinese. (C) 2000 Wiley-Liss, Inc.
Source Title: American Journal of Medical Genetics - Neuropsychiatric Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/113667
ISSN: 15524841
Appears in Collections:Staff Publications

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