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|Title:||Membranous nephropathy with anti-tubular basement membrane antibody may be X-linked||Authors:||Tay, A.H.N.
|Keywords:||Anti-tubular basement membrane antibodies
Familial membranous nephropathy
|Issue Date:||Aug-2000||Citation:||Tay, A.H.N.,Ren, E.-C.,Murugasu, B.,Sim, S.-K.,Tan, P.-H.,Cohen, A.H.,Yap, H.-K. (2000-08). Membranous nephropathy with anti-tubular basement membrane antibody may be X-linked. Pediatric Nephrology 14 (8-9) : 747-753. ScholarBank@NUS Repository.||Abstract:||The association of membranous nephropathy with Fanconi syndrome and anti-tubular basement antibodies appears to be a distinct subset of familial membranous nephropathy. We studied two Chinese families with four affected boys to evaluate the mode of inheritance of disease. HLA haplotype analysis of the family members in these two pedigrees did not reveal any significant linkages. However, microsatellite analysis of both pedigrees using markers on the X chromosome suggested linkage to the long arm of the X chromosome between the; microsatellite markers DXS1001 and DXS1227. Identification and analysis of additional pedigrees may allow more precise mapping of the disease gene for anti-tubular basement membrane antibody-associated membranous nephropathy.||Source Title:||Pediatric Nephrology||URI:||http://scholarbank.nus.edu.sg/handle/10635/113545||ISSN:||0931041X|
|Appears in Collections:||Staff Publications|
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