Please use this identifier to cite or link to this item:;2-T
Title: Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation
Authors: Korzh, V. 
Sleptsova, I. 
Liao, J.
He, J. 
Gong, Z. 
Keywords: Determination
Neural retina
Neuronal bHLH
Primary neurons
Issue Date: Sep-1998
Citation: Korzh, V.,Sleptsova, I.,Liao, J.,He, J.,Gong, Z. (1998-09). Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Developmental Dynamics 213 (1) : 92-104. ScholarBank@NUS Repository.;2-T
Abstract: Two zebrafish bHLH genes, neurogenin-related gene I (ngn1) and neuroD (nrd), have been isolated. ngn1 expression is initiated at the end of gastrulation in the neural plate and defines broad domains of cells that probably possess an ability to develop as neurons. This finding suggests that ngn1 may play a role during determination of cell fate in neuroblasts. ngn1 and pax-b are expressed in a mutually exclusive manner. nrd expression follows that of ngn1 in restricted populations of cells selected from ngn1- positive clusters of cells. The earliest nrd-positive cells in the brain and the trunk are a subset of the primary neurons. ngn1 is not expressed in the eye. Here, nrd transcription is activated at 25 hours postfertilization in the ventral retina. Expression of islet-1 occurs in nrd-positive cells after expression of nrd, and the expression of the two genes partially overlaps in time. These observations suggest that during eye development nrd expression may follow expression of some other neurodetermination gene(s). This supports the idea that expression of nrd is a necessary step leading toward overt neuronal differentiation.
Source Title: Developmental Dynamics
ISSN: 10588388
DOI: 10.1002/(SICI)1097-0177(199809)213:13.0.CO;2-T
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Jul 19, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.