Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00018-011-0892-2
Title: CHFR: A key checkpoint component implicated in a wide range of cancers
Authors: Sanbhnani, S.
Yeong, F.M. 
Keywords: Cancers
Checkpoint
CHFR
Entry into mitosis
Microtubules
Promoter hypermethylation
Issue Date: May-2012
Citation: Sanbhnani, S., Yeong, F.M. (2012-05). CHFR: A key checkpoint component implicated in a wide range of cancers. Cellular and Molecular Life Sciences 69 (10) : 1669-1687. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-011-0892-2
Abstract: CHFR (Checkpoint with Forkhead-associated and RING finger domains) has been implicated in a checkpoint regulating entry into mitosis. However, the details underlying its roles and regulation are unclear due to conflicting lines of evidence supporting different notions of its functions. We provide here an overview of how CHFR is thought to contribute towards regulating mitotic entry and present possible explanations for contradictory observations published on the functions and regulation of CHFR. Furthermore, we survey key data showing correlations between promoter hypermethylation or down-regulation ofCHFRand cancers, with a view on the likely reasons why different extents of correlations have been reported. Lastly, we explore the possibilities of exploiting CHFR promoter hypermethylation status in diagnostics and therapeutics for cancer patients. With keen interest currently focused on the association between hypermethylation of CHFR and cancers, details of how CHFR functions require further study to reveal how its absence might possibly contribute to tumorigenesis. © 2011 Springer Basel AG.
Source Title: Cellular and Molecular Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/112185
ISSN: 1420682X
DOI: 10.1007/s00018-011-0892-2
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